Enhance Liver Health
- Promote liver detoxification and improve certain liver markers in plasma
- Protect liver from alcohol-induced oxidative stress and maintain healthy liver function
- Repair damaged liver cells and aid in liver-related challenges
In a peer-reviewed human study on 85 participants with liver stress, the effectiveness of Siliphos® as a beneficial
approach for promoting a healthy liver was examined. The study aimed to evaluate the impact of Siliphos® administration on liver enzyme levels and other relevant markers.
The results revealed that Siliphos® administration had a positive effect on liver health indicators, independently of the individual's body mass index (BMI). Notably,Siliphos® optimized insulinemia, alanine aminotransferase (ALT), and γ-glutamyl transpeptidase (γ-GT) levels.
These findings suggest that Siliphos® could be considered an effective intervention for improving liver function in cases of liver stress. [1,2]
Significantly Optimized Bioavailability
- Siliphos® greatly improved the absorption of silybin through Phytosome® technology
- The active compound of milk thistle, silybin, is often characterized as poor absorption, with overall 0.95% rate through oral administration
- Siliphos®’s highest bioavailability resulted in 7 times more effectiveness in liver support than simple milk thistle extract
- In a comparative study, the oral administration of simple silybin resulted in plasma levels and its conjugated metabolites that were below the detection limit of the analytical methods used. However, following the oral administration of Siliphos®, plasma levels of silybin were easily detectable. This enhanced detectability is attributed to the Phytosome formulation, which facilitates rapid absorption within a few minutes.
- Another study compared the administration of Siliphos® and simple silymarin. The results showed that silybin was detectable in plasma within a few minutes of Siliphos® administration, reaching its peak concentration after 1 hour. Furthermore, the plasma levels of silybin remained stable for over 6 hours.
These findings highlight the superior bioavailability of silybin achieved through the use of Siliphos®. The Phytosome formulation enables rapid absorption and sustained plasma levels of silybin. [3,4]
Figure 1: Plasma silybin profile after Siliphos® (upper line)and simple silybin (lower line) administration.
[1] Loguercio, C., Federico, A., Trappoliere, M., Tuccillo, C., de Sio, I., Di Leva, A., Niosi, M., D'Auria, M. V., Capasso, R., Del Vecchio Blanco, C., & Real Sud Group. (2007). The effect of a silybin-vitamin e-phospholipid complex on nonalcoholic fatty liver disease: A pilot study. Digestive Diseases and Sciences, 52(9), 2387-2395.
[2] Vailati, A., et al. (1993). Randomized open study of the dose-effect relationship of a short course of IdB 1016 in patients with viral or alcoholic hepatitis. Fitoterapia, 64, 219.
[3] Morazzoni, P., Magistretti, M. J., Giachetti, C., & Zanolo, G. (1992). Comparative bioavailability of Silipide, a new flavanolignan complex, in rats. European Journal of Drug Metabolism and Pharmacokinetics, 17, 39-44.
[4] Morazzoni, P., Montalbetti, A., Malandrino, S., & Pifferi, G. (1993). Comparative pharmacokinetics of silipide and silymarin in rats. European Journal of Drug Metabolism and Pharmacokinetics, 18, 289-297.